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[应激状态下T淋巴细胞对红系及粒单核系定向祖细胞增殖活性的调控]

[T-lymphocyte control over the proliferative activity of committed precursor cells of erythro- and granulomonocytopoesis in stress].

作者信息

Dygaĭ A M, Shakhov V P, Gol'dberg E D

出版信息

Biull Eksp Biol Med. 1990 Nov;110(11):531-3.

PMID:2083339
Abstract

The role of T-lymphocytes in regulation of proliferation and differentiation processes of committed myelopoiesis cell precursors in F1 (CBA-C57Bl/6) mice, treated by 10-hour immobilization was studied. One of the first reactions of hemopoietic precursors at stress was estimated to be the increase of active proliferating cells-precursors, accompanied by the quantitative changes of their content. The creation of T-cell deficit by means of anti-thymic serum resulted in abolition of the above mentioned changes of erythroid and granulo-macrophage precursors marked in the processes of adaptation syndrome development.

摘要

研究了经10小时固定处理的F1(CBA-C57Bl/6)小鼠中T淋巴细胞在定向髓系造血细胞前体增殖和分化过程调控中的作用。应激时造血前体的首批反应之一据估计是活性增殖细胞前体的增加,同时伴随着其含量的定量变化。通过抗胸腺血清造成T细胞缺乏,导致在适应综合征发展过程中所标记的红系和粒-巨噬细胞前体的上述变化消失。

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