Dygaĭ A M, Khlusov I A, Shakhov V P
Patol Fiziol Eksp Ter. 1991 May-Jun(3):14-7.
It was demonstrated in experiments on rats that a neuroleptic and alpha-adrenergic blocking agent inhibited whereas a ganglion blocking agent and beta-adrenergic blocking agent delayed activation of granulocytopoiesis in immobilization stress, while M-cholinergic blocking agent had practically no effect on this process. Blockade of alpha- or beta-adrenergic receptors causes an essential reduction in the number of hematopoietic islets, precursor cells of granulocytopoiesis in the bone marrow, and level of colony stimulating activity in blood serum and supernatants of lipopolysaccharides and concanavalin-A stimulated myelokaryocytes. However, in immobilization stress the initiator and potentiator effect of stimulation of beta-adrenergic blocking agents on processes of granulocytopoiesis was much less marked than that of alpha-adrenergic blocking agents stimulation.
在对大鼠的实验中表明，一种抗精神病药和α-肾上腺素能阻断剂会抑制粒细胞生成的激活，而一种神经节阻断剂和β-肾上腺素能阻断剂会延迟固定应激中粒细胞生成的激活，而M-胆碱能阻断剂对这一过程几乎没有影响。α-或β-肾上腺素能受体的阻断会导致造血岛数量、骨髓中粒细胞生成的前体细胞数量以及脂多糖和伴刀豆球蛋白A刺激的骨髓细胞的血清和上清液中的集落刺激活性水平显著降低。然而，在固定应激中，β-肾上腺素能阻断剂刺激对粒细胞生成过程的启动和增强作用远不如α-肾上腺素能阻断剂刺激明显。
