[The adrenergic mechanisms controlling the proliferation and differentiation of hematopoietic precursor cells under immobilization stress].

The role of adrenergic structures in mechanisms of erythro- and granulomonocytopoiesis precursor cell proliferation and differentiation under immobilization stress was antagonist administration inhibited stress-induced rise of erythroid, erythrogranulocyte and granulocyte hemopoietic islets erythrogranulocyte and granulocyte hemopoietic islets forming in the bone marrow. In vitro the alpha-adrenergic agonist had a direct activating effect on CFU-GM but on CFU-E growth in normal state (10(-5) M) and after immobilization (10(-9), 10(-7) M). At the same time beta-adrenergic agonist (10(-5) M) increased exclusively CFU-E growth after extreme influence. Thus, adrenergic mechanisms are of great importance in direct (receptor) and microenvironmental hemopoiesis-induced stimulation of the processes of proliferation and differentiation of hemopoietic precursors during stress.