Gol'dberg E D, Khlusov I A, Dygaĭ A M, Agafonov V I
Biull Eksp Biol Med. 1993 Nov;116(11):457-60.
The role of adrenergic structures in mechanisms of erythro- and granulomonocytopoiesis precursor cell proliferation and differentiation under immobilization stress was antagonist administration inhibited stress-induced rise of erythroid, erythrogranulocyte and granulocyte hemopoietic islets erythrogranulocyte and granulocyte hemopoietic islets forming in the bone marrow. In vitro the alpha-adrenergic agonist had a direct activating effect on CFU-GM but on CFU-E growth in normal state (10(-5) M) and after immobilization (10(-9), 10(-7) M). At the same time beta-adrenergic agonist (10(-5) M) increased exclusively CFU-E growth after extreme influence. Thus, adrenergic mechanisms are of great importance in direct (receptor) and microenvironmental hemopoiesis-induced stimulation of the processes of proliferation and differentiation of hemopoietic precursors during stress.
在固定应激状态下，肾上腺素能结构在红细胞和粒单核细胞生成前体细胞增殖与分化机制中的作用是，拮抗剂给药可抑制应激诱导的骨髓中形成的红系、红粒系和粒系造血岛数量增加。在体外，α-肾上腺素能激动剂对正常状态（10⁻⁵M）及固定后（10⁻⁹、10⁻⁷M）的CFU-GM有直接激活作用，但对CFU-E生长无此作用。同时，β-肾上腺素能激动剂（10⁻⁵M）在极端影响后仅增加CFU-E生长。因此，肾上腺素能机制在应激期间对造血前体细胞增殖和分化过程的直接（受体）和微环境造血诱导刺激中具有重要意义。
