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子痫前期是女性特有的慢性高血压危险因素。

Preeclampsia as a female-specific risk factor for chronic hypertension.

机构信息

Isala Klinieken, Department of Cardiology, Zwolle, The Netherlands.

出版信息

Maturitas. 2010 Dec;67(4):321-6. doi: 10.1016/j.maturitas.2010.08.002. Epub 2010 Sep 15.

Abstract

Preeclampsia is a complication of pregnancy that has also long term effects on maternal health. Several epidemiologic studies have shown an increased risk for cardiovascular morbidity (relative risk [RR] 2.3) and mortality (RR 2.3) in women after a history of preeclampsia. The chance to develop chronic hypertension afterwards is twofold to 10 times higher in affected women, compared with women after normotensive pregnancies. As hypertension is a major cardiovascular risk factor, early detection and treatment is mandatory to reduce the risk of future cardiovascular disease. Data on (cost)-effectiveness of cardiovascular screening programs in women after preeclampsia are currently lacking and there are no recommendations yet for prevention in the guidelines. We recommend regularly preventive blood pressure measurements after high risk pregnancies. More research is needed to identify women who will profit most of early intervention.

摘要

子痫前期是一种妊娠并发症,也会对产妇的健康产生长期影响。多项流行病学研究表明,有子痫前期病史的女性发生心血管疾病发病率(相对风险 [RR] 2.3)和死亡率(RR 2.3)的风险增加。与正常妊娠后的女性相比,受影响的女性随后发生慢性高血压的几率增加两倍至十倍。由于高血压是主要的心血管危险因素,因此必须早期发现和治疗,以降低未来发生心血管疾病的风险。目前,子痫前期后女性心血管筛查计划的(成本)效益数据尚缺乏,指南中也没有关于预防的建议。我们建议高危妊娠后定期进行预防性血压测量。需要进一步研究以确定哪些女性将从早期干预中获益最大。

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