Timofeeva L V, Kelesheva L F, Sudakov K V
Biull Eksp Biol Med. 1990 Dec;110(12):567-71.
The influence of protein blocker cycloheximide on the ethanol intake in alcohol-dependent rats was studied. It was found that intracerebroventricular as well as perifornical area hypothalamus injection of cycloheximide caused inhibition of ethanol consumption in alcohol-dependent rats, persisting for 5-9 weeks. The blockade action of cycloheximide was more strong after its injection in phase of decreased ethanol intake. At the same time it was shown an increase in water and food intake. The blockade action of cycloheximide on ethanol intake was not found in alcohol-dependent rats. These data indicate that some protein substances take part in mechanisms of organization of alcohol motivation and dependence.
研究了蛋白质阻断剂放线菌酮对酒精依赖大鼠乙醇摄入量的影响。发现向酒精依赖大鼠脑室内以及下丘脑穹窿周区注射放线菌酮会导致乙醇消耗量受到抑制，这种抑制持续5至9周。在乙醇摄入量减少阶段注射放线菌酮后，其阻断作用更强。同时还发现水和食物摄入量增加。在非酒精依赖大鼠中未发现放线菌酮对乙醇摄入量的阻断作用。这些数据表明，某些蛋白质物质参与了酒精动机形成和依赖的机制。
