Karegezian K G, Safarian M D
Biull Eksp Biol Med. 1990 Dec;110(12):600-2.
Lung tissue phospholipid metabolism has been studied under the conditions of experimental tuberculosis. These investigations were combined with the simultaneous studying of the qualitative and quantitative composition of individual phospholipids, of the changes in the content of glycerophosphate and dioxiacetonphosphate, as well as, of the abnormalities in the activity of glycerokinase and glycerophosphatedehydrogenase, which play an important role in the catalysis of the initial processes of phosphatidogenesis. Our data obtained have shown that formation of tuberculosis process is accompanied by the pronounced increase of glycerokinase and glycerophosphatedehydrogenase activities, which leads to the significant accumulation of the dioxiacetonphosphate and the free glycerol concentrations. It was established by us, that under the conditions of the pathology studied, the significant decrease of the quantity of phosphatidylcholines, phosphatidylethanolamines and phosphatidylserines took place, while the level of sphingomyelins was increased. The results of our investigations shed the light on the up-to-date understanding of the role of different fractions of phospholipids, as well as, of corresponding enzymatic systems in the pathogenesis of lung tuberculosis and in the formation of focus of necrosis in lung tissue.
在实验性结核病的条件下，对肺组织磷脂代谢进行了研究。这些研究同时结合了对单个磷脂的定性和定量组成、甘油磷酸和二羟基丙酮磷酸含量的变化，以及甘油激酶和甘油磷酸脱氢酶活性异常的研究，这些酶在磷脂生成的初始过程催化中起重要作用。我们获得的数据表明，结核病过程的形成伴随着甘油激酶和甘油磷酸脱氢酶活性的显著增加，这导致二羟基丙酮磷酸和游离甘油浓度的显著积累。我们确定，在所研究的病理条件下，磷脂酰胆碱、磷脂酰乙醇胺和磷脂酰丝氨酸的数量显著减少，而鞘磷脂水平升高。我们的研究结果为深入了解不同磷脂组分以及相应酶系统在肺结核发病机制和肺组织坏死灶形成中的作用提供了线索。
