Shloznikov B M, Korotkina R N, Babkina N V, Karelin A A, Fomchenkov E P
Biull Eksp Biol Med. 1990 Dec;110(12):609-10.
The cholestasis and pancreatitis model was studied experimentally in 144 white rats. The influence of intraperitoneal injections of dalargin on the level of lipid peroxidation and on xanthine oxidase activity of the liver tissues in periods of 1, 3 and 5 hours was investigated. During that period the activity of hepato-specific enzymes in the liver tissues and serum were investigated. The reduction of xanthine oxidase activity in all the periods after injection of dalargin was discovered, the level of malonic dialdehyde was reduced by 43.8% 3 hours later. Simultaneously, the increase of the level of histidase in liver tissues was discovered (on 104.3% and 56.3% after 3 and 5 hours accordingly) and later the tendency to decrease the activity in serum was observed.
在144只白色大鼠身上对胆汁淤积和胰腺炎模型进行了实验研究。研究了腹腔注射达来金在1小时、3小时和5小时期间对肝脏组织脂质过氧化水平和黄嘌呤氧化酶活性的影响。在此期间，对肝脏组织和血清中肝特异性酶的活性进行了研究。发现注射达来金后所有时间段黄嘌呤氧化酶活性均降低，3小时后丙二醛水平降低了43.8%。同时，发现肝脏组织中组氨酸酶水平升高（3小时和5小时后分别升高104.3%和56.3%），随后观察到血清中其活性有降低的趋势。
