Korotkina R N, Fomchenkov E P, Babkina N V, Andreev V I, Shloznikov B M, Karelin A A
Patol Fiziol Eksp Ter. 1990 Jul-Aug(4):42-4.
Experiments were conducted on 182 rats with acute cholestasis to study the effect of intra-abdominal dalargin injection (10 mcg/kg) with the serotonin antagonist ketanserine (150 mg/kg) on xanthine oxidase (XO) activity and level of lipid peroxidation in the hepatic tissue and on the activity of the hepatospecific enzymes histidase and urokaninase in hepatic tissue and blood serum 1, 3, and 5 hours after the injection. Dalargin reduced XO activity by 32-37% in different periods after the injection, dalargin in combination with ketanserine--by 37-48%. Dalargin reduced the level of lipid peroxidation by 29-35%, and when combined with ketanserine--by 37-49%. The administration of dalargin reveals a distinct tendency towards reduction of the release of the hepatospecific enzymes histidase and urokanase into the blood and increase of their activity in the hepatic tissue. Dalargin with ketanserine produces a similar effect but of a higher degree. These data allow us to speak of the hepatoprotective effect of dalargin, which is potentiated by its injection together with ketanserine. It was found that dalargin (50 mcg/kg, intraperitoneally) increases the leu-enkephalin content in the hepatic tissue more than 3.5 fold one hour after injection.
对182只急性胆汁淤积大鼠进行实验，以研究腹腔注射达乐argin（10微克/千克）与5-羟色胺拮抗剂酮色林（150毫克/千克）对肝组织中黄嘌呤氧化酶（XO）活性、脂质过氧化水平以及对肝组织和血清中肝特异性酶组氨酸酶和尿刊酸酶活性在注射后1、3和5小时的影响。达乐argin在注射后的不同时间段使XO活性降低32 - 37%，达乐argin与酮色林联合使用时降低37 - 48%。达乐argin使脂质过氧化水平降低29 - 35%，与酮色林联合使用时降低37 - 49%。注射达乐argin显示出肝特异性酶组氨酸酶和尿刊酸酶向血液中释放减少以及其在肝组织中活性增加的明显趋势。达乐argin与酮色林共同作用产生类似效果，但程度更高。这些数据使我们能够谈及达乐argin的肝保护作用，其与酮色林一起注射可增强这种作用。发现达乐argin（50微克/千克，腹腔注射）在注射后1小时使肝组织中亮氨酸脑啡肽含量增加超过3.5倍。
