L'vova S P, Gorbunova T F, Abaeva E M
Vopr Med Khim. 1993 May-Jun;39(3):21-4.
The rate of lipid peroxidation was studied in rat brain, liver, skeletal muscles and myocardial tissues in dynamics of hypothermia. Cooling of the animals down to 30 degrees induced lipid peroxidation, which was markedly expressed within 3-hour continuation of the treatment. Profound hypothermia (20 degrees) increased levels of malonic dialdehyde in the tissues studied by 30-160%, while prolongation of the impairment up to 3 hrs resulted in normalization of the lipid peroxidation parameters studied. The artificial hexapeptide dalargin, similar to leu-enkephalin, inhibited the rate of lipid peroxidation in profound hypothermia both in vivo and in vitro.
在低温动态过程中，对大鼠脑、肝、骨骼肌和心肌组织中的脂质过氧化速率进行了研究。将动物体温降至30度会诱导脂质过氧化，在治疗持续3小时内这种现象明显表现出来。深度低温（20度）使所研究组织中的丙二醛水平升高30%-160%，而将损伤延长至3小时导致所研究的脂质过氧化参数恢复正常。人工六肽达拉argin，类似于亮氨酸脑啡肽，在体内和体外均能抑制深度低温下的脂质过氧化速率。
