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[外周肾上腺素能联系在大鼠行为性抑郁实验模型抗抑郁作用发展中的作用]

[Role of peripheral adrenergic links in the development of antidepressive effect in an experimental model of behavioral depression in rats].

作者信息

Khaĭsman E B, Kushnarev V V

出版信息

Biull Eksp Biol Med. 1990 Dec;110(12):620-3.

PMID:2083363
Abstract

The study was made on the reserpine model of behavioural depression in cats. The morphofunctional state of peripheral adrenergic nerves in control experiments and under action of antidepressants (befol and nialamid) was studied by fluorescent microscopic method. One definite correlation was shown between the state of somatovegetative changes and the level of neuromediator activity of the adrenergic structures. It was established that the used antidepressants (more expressive by befol) have protective effect in depressive conditions.

摘要

该研究以猫的利血平行为性抑郁模型进行。通过荧光显微镜法研究了对照实验以及在抗抑郁药(贝福洛尔和尼亚酰胺)作用下外周肾上腺素能神经的形态功能状态。结果表明,躯体植物性变化状态与肾上腺素能结构的神经介质活性水平之间存在一定的相关性。已证实所使用的抗抑郁药(贝福洛尔表现更为明显)在抑郁状态下具有保护作用。

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