[抗氧化剂对抗胆碱酯酶药物膜毒性作用的影响]
[Action of antioxidants on membrane-toxic effects of anticholinesterase agents].
作者信息
Zatsepin E P, Churaev N N, Uspenskaia T A, Tirzit G D, Dubur G Ia
出版信息
Biull Eksp Biol Med. 1990 Dec;110(12):623-4.
PMID:2083364
Abstract
It was found therapeutic-preventive effectiveness of antioxidants (1,4-dihydropyridine derivatives) at poisoning with malathion insecticide. The effect of 1,4-dihydropyridine derivatives can be attributed to a prevention of lipid peroxidation. Antioxidants do not affect the toxicity of 0,0-dimethyl-0-2,2-dichlorvinylphosphate. Thus, antioxidants are pathogenetic drugs for treatment of poisonings with cholinesterase inhibitors.
摘要
研究发现抗氧化剂（1,4 - 二氢吡啶衍生物）对马拉硫磷杀虫剂中毒具有治疗 - 预防效果。1,4 - 二氢吡啶衍生物的作用可归因于对脂质过氧化的预防。抗氧化剂不影响0,0 - 二甲基 - 0 - 2,2 - 二氯乙烯基磷酸酯的毒性。因此，抗氧化剂是用于治疗胆碱酯酶抑制剂中毒的病因性药物。
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