[抗氧化剂对二乙基亚硝胺生物转化早期肝微粒体脂质过氧化速率的修饰作用]
[Modifying effect of antioxidants on the rate of lipid peroxidation in liver microsomes at early stages of diethylnitrosamine biotransformation].
作者信息
Pakhomov V Iu, Artemova L G, Shuliakovskaia T S
出版信息
Eksp Onkol. 1988;10(5):20-3.
PMID:3208683
Abstract
Lipid peroxidation and free radicals' generation were investigated in rats treated with carcinogenic diethylnitrosamine (DENA) after pretreatment with some antioxidants. It was shown that decreased generation of free radicals during DENA metabolism in rat liver microsomes after pretreatment of animals with antioxidants may be the cause of the protective action of these antioxidants against DENA toxicity. Lipid peroxidation was shown to be not a crucial reaction in the toxic effect of DENA.
摘要
在用一些抗氧化剂预处理后，研究了用致癌物质二乙基亚硝胺（DENA）处理的大鼠体内的脂质过氧化和自由基生成情况。结果表明，在用抗氧化剂预处理动物后，大鼠肝微粒体中DENA代谢过程中自由基生成减少可能是这些抗氧化剂对DENA毒性具有保护作用的原因。脂质过氧化在DENA的毒性作用中并非关键反应。
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