Marbach J J, Schleifer S J, Keller S E
Division of Sociomedical Sciences, School of Public Health, Columbia University, New York, New York 10032.
Brain Behav Immun. 1990 Sep;4(3):243-54. doi: 10.1016/0889-1591(90)90026-m.
Chronic facial pain syndromes are associated with high levels of distress and depression. Immune system measures were investigated in otherwise healthy patients suffering from chronic temporomandibular pain and dysfunction syndrome (TMPDS) and in matched controls. No mean differences were found between TMPDS patients and the controls on any of the immune measures; however, both ConA and PWM responses in TMPDS patients were decreased in relation to the level of demoralization (P less than 0.05). Cognitive symptoms such as low self-esteem and perceptions of helplessness/hopelessness were implicated in these effects. In addition, among patients pain severity was independently associated with decreased ConA response (P less than 0.05). The data suggest possible correlates of stress-induced changes in the immune system.
慢性面部疼痛综合征与高度的痛苦和抑郁相关。对患有慢性颞下颌疼痛和功能障碍综合征（TMPDS）的健康患者及配对对照组进行了免疫系统指标检测。在任何一项免疫指标上，TMPDS患者与对照组之间均未发现均值差异；然而，TMPDS患者的刀豆蛋白A（ConA）和美洲商陆有丝分裂原（PWM）反应均与士气低落程度呈负相关（P<0.05）。这些效应涉及诸如自卑以及无助感/绝望感等认知症状。此外，在患者中，疼痛严重程度与ConA反应降低独立相关（P<0.05）。这些数据提示了应激诱导的免疫系统变化可能存在的相关因素。
