Schleifer S J, Marbach J, Keller S E
University of Medicine and Dentistry of New Jersey, Newark.
Anesth Prog. 1990 Mar-Jun;37(2-3):93-8.
Studies undertaken over the past ten years have demonstrated that stress and depression can induce immune alterations, including decreased numbers of immunocompetent cells and impaired lymphocyte and natural killer cell activity. Factors such as age and severity of symptomatology influence these effects. The substantial stress and depression associated with chronic pain syndromes and the evidence for opioid involvement in immunomodulation suggest that immune system changes may occur in some patients with chronic facial pain.
过去十年进行的研究表明，压力和抑郁会引起免疫改变，包括免疫活性细胞数量减少以及淋巴细胞和自然杀伤细胞活性受损。年龄和症状严重程度等因素会影响这些效应。与慢性疼痛综合征相关的巨大压力和抑郁，以及阿片类药物参与免疫调节的证据表明，一些慢性面部疼痛患者可能会出现免疫系统变化。
