蛋白酶在三种溶剂体系中催化2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的单酰化反应。
Protease-catalyzed monoacylation of 2-O-α-D-glucopyranosyl-L-ascorbic acid in three solvent systems.
作者信息
Tai Akihiro, Iwaoka Yuji, Mori Tasuku, Ito Hideyuki
机构信息
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima.
出版信息
Biosci Biotechnol Biochem. 2010;74(9):1969-71. doi: 10.1271/bbb.100362. Epub 2010 Sep 7.
6-O-dodecanoyl-2-O-α-D-glucopyranosyl-L-ascorbic acid (6-sDode-AA-2G) was synthesized from 2-O-α-D-glucopyranosyl-L-ascorbic acid and vinyl laurate with a protease from Bacillus subtilis in 30% dimethylformamide (DMF)/dioxane with a low water content. The addition of 3% (v/v) water to DMF/dioxane dramatically enhanced the 6-sDode-AA-2G synthesis. The optimum reaction conditions enabled 6-sDode-AA-2G to be synthesized in a yield of 38.1%.
6-O-十二烷酰基-2-O-α-D-吡喃葡萄糖基-L-抗坏血酸（6-sDode-AA-2G）由2-O-α-D-吡喃葡萄糖基-L-抗坏血酸和月桂酸乙烯酯在含水量低的30%二甲基甲酰胺（DMF）/二氧六环中，用枯草芽孢杆菌的一种蛋白酶合成。向DMF/二氧六环中添加3%（v/v）的水显著提高了6-sDode-AA-2G的合成。最佳反应条件使得6-sDode-AA-2G能够以38.1%的产率合成。
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