Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
Chem Commun (Camb). 2010 Oct 28;46(40):7516-8. doi: 10.1039/c0cc02663h. Epub 2010 Sep 10.
Here we describe the use of simple 1-pot thiol exchange reactions to generate a library of mixed ligand-coated gold nanoparticles that was screened for antibiotic activity. A library of 120 nanoparticle conjugates was assembled and antibiotic activity toward E. coli was determined and found to depend upon the combination of thiols assembled onto the nanoparticles. The most active conjugate displayed 99.9% growth inhibition at 0.5 μM.
在这里，我们描述了使用简单的一锅巯基交换反应来生成混合配体涂覆的金纳米粒子文库，并对其进行了抗生素活性筛选。我们组装了一个包含 120 种纳米粒子缀合物的文库，并测定了它们对大肠杆菌的抗生素活性，发现其活性取决于组装在纳米粒子上的硫醇的组合。最有效的缀合物在 0.5 μM 时表现出 99.9%的生长抑制。
