Frohn J, Baum R P, Happ J, Falk S, Riemann H E, Hör G
Department of Radiology, Frankfurt University Medical Center, Federal Republic of Germany.
Eur J Nucl Med. 1990;17(1-2):91-3. doi: 10.1007/BF00819410.
A female patient with steadily increasing carcinoembryonic antigen (CEA) serum levels of unknown origin was referred for immunoscintigraphy with indium 111-labelled CEA-specific monoclonal antibody. The procedure revealed a tumour, undetectable by conventional diagnostic methods. Anatomical landmarking using the second tracer isocontour technique allowed the distinction between an intra- or extrapulmonary lesion. Two months later, tumour infiltration along the aortic arch was confirmed by a targeted angio-CT scan. Upon surgery, the diagnosis was definitely established histologically (undifferentiated, solid large cell carcinoma, most probably arising from the bronchus), and staining by CEA-specific immunohistochemistry confirmed the presence of the CEA antigen.
一名癌胚抗原（CEA）血清水平持续升高且病因不明的女性患者被转诊接受用铟111标记的CEA特异性单克隆抗体进行免疫闪烁扫描。该检查发现了一个传统诊断方法无法检测到的肿瘤。使用第二种示踪剂等剂量轮廓技术进行解剖定位，可区分肺内或肺外病变。两个月后，靶向血管CT扫描证实肿瘤沿主动脉弓浸润。手术时，通过组织学明确诊断（未分化实性大细胞癌，很可能起源于支气管），CEA特异性免疫组化染色证实存在CEA抗原。
