College of Biological and Environmental Engineering, Zhejiang University of Technology, No 6 District Zhaohui, Zhejiang, 310032 Hangzhou, China.
Mol Biol Rep. 2011 Mar;38(3):1533-40. doi: 10.1007/s11033-010-0261-5. Epub 2010 Sep 12.
BRAND's Essence of Chicken (BEC) has been widely used as a traditional remedy by people in Southeast Asia, which is proved to have an effect on the central nervous system (CNS) and autonomic nervous system (ANS). However, whether and how BEC consumption may affect mammalian circadian system is still largely unknown. In the present study, we investigated the effect of BEC feeding on the adaptation of circadian clocks to the experimental jet lag in rats. After the 12-h experimental jet lag through extending the light period, BEC feeding markedly facilitated the re-entrainment of all examined clock genes (Bmal1, Cry1, Per1, and Per2) in the pineal gland. The resetting time course of pineal clock genes was reduced from 7 days to only 3-5 days by BEC feeding, which was almost equal to the effect of melatonin feeding. In the liver clock, the facilitating effect of BEC feeding was mainly displayed in the re-entrainment of Bmal1 and Per2 by shortening their resetting processes for nearly 2 days. However, the resetting rate of locomotor activity rhythm was not affected by BEC feeding, suggesting that BEC might be unable to affect the behavioral rhythm.
BRAND's Essence of Chicken (BEC) 作为一种传统的药物，在东南亚地区被广泛使用，它被证明对中枢神经系统 (CNS) 和自主神经系统 (ANS) 有影响。然而，BEC 的摄入是否以及如何影响哺乳动物的昼夜节律系统，在很大程度上还不清楚。在本研究中，我们研究了 BEC 喂养对大鼠生物钟适应实验性时差的影响。在通过延长光照期造成 12 小时的实验性时差后，BEC 喂养明显促进了松果体中所有被检测到的生物钟基因（Bmal1、Cry1、Per1 和 Per2）的重新同步。松果体生物钟基因的重置时间过程从 7 天缩短到 3-5 天，BEC 喂养的效果几乎与褪黑素喂养的效果相同。在肝脏生物钟中，BEC 喂养的促进作用主要表现在 Bmal1 和 Per2 的重新同步，它们的重置过程缩短了近 2 天。然而，BEC 喂养并没有影响运动活动节律的重置率，这表明 BEC 可能无法影响行为节律。
