Gangitano Elena, Baxter Matthew, Voronkov Maria, Lenzi Andrea, Gnessi Lucio, Ray David
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Front Nutr. 2023 Aug 23;10:1166699. doi: 10.3389/fnut.2023.1166699. eCollection 2023.
Sleep disturbances are an emerging risk factor for metabolic diseases, for which the burden is particularly worrying worldwide. The importance of sleep for metabolic health is being increasingly recognized, and not only the amount of sleep plays an important role, but also its quality. In this review, we studied the evidence in the literature on macronutrients and their influence on sleep, focusing on the mechanisms that may lay behind this interaction. In particular, we focused on the effects of macronutrients on circadian and homeostatic processes of sleep in preclinical models, and reviewed the evidence of clinical studies in humans. Given the importance of sleep for health, and the role of circadian biology in healthy sleep, it is important to understand how macronutrients regulate circadian clocks and sleep homeostasis.
睡眠障碍是代谢性疾病新出现的一个风险因素，其负担在全球范围内尤其令人担忧。睡眠对代谢健康的重要性正日益得到认可，不仅睡眠时长起着重要作用，睡眠质量也很重要。在这篇综述中，我们研究了文献中关于常量营养素及其对睡眠影响的证据，重点关注这种相互作用背后可能存在的机制。特别是，我们关注了常量营养素在临床前模型中对睡眠昼夜节律和稳态过程的影响，并回顾了人体临床研究的证据。鉴于睡眠对健康的重要性以及昼夜节律生物学在健康睡眠中的作用，了解常量营养素如何调节生物钟和睡眠稳态非常重要。
