Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-046 Zielona Gora, Poland.
Department of Biological and Medical Basis of Sport, Faculty of Physical Education and Sport, Wrocław University of Sport and Health Sciences, 51-612 Wrocław, Poland.
Nutrients. 2022 Jun 9;14(12):2402. doi: 10.3390/nu14122402.
Exposure to intense physical exercise increases reactive oxygen and nitrogen species production. The process can be modulated by dipeptide bioavailability with antioxidant scavenger properties. The effects of dipeptide intake in combination with physical exercise on the oxi-antioxidant response were examined in a randomized and placebo-controlled trial. Blood samples were collected from 20 males aged 21.2 ± 1.8 years before and after 14-day intake of chicken breast extract (4 g/day), which is a good source of bioactive dipeptides. A significant increase in the NO/HO ratio was observed in the 1st and 30th minute after intense incremental exercise in dipeptides compared to the placebo group. Total antioxidant and thiol redox status were significantly higher in the dipeptide group both before and after exercise; ≥ 0.64 showed a large effect of dipeptides on antioxidant and glutathione status. The level of 8-isoprostanes, markers of oxidative damage, did not change under the influence of dipeptides. By contrast, reduced C-reactive protein levels were found during the post-exercise period in the dipeptide group, which indicates the anti-inflammatory properties of dipeptides. High pre-exercise dipeptide intake enhances antioxidant status and thus reduces the oxi-inflammatory response to intense exercise. Therefore, the application of dipeptides seems to have favourable potential for modulating oxidative stress and inflammation in physically active individuals following a strenuous exercise schedule.
剧烈的身体运动增加活性氧和氮物种的产生。该过程可以通过具有抗氧化清除特性的二肽生物利用度来调节。在一项随机对照试验中，研究了二肽摄入与身体运动相结合对氧化抗氧化反应的影响。从 20 名年龄在 21.2 ± 1.8 岁的男性中采集血液样本，这些男性在 14 天内每天摄入 4 克鸡胸肉提取物，这是生物活性二肽的良好来源。与安慰剂组相比，在剧烈递增运动的第 1 分钟和第 30 分钟，二肽组的 NO/HO 比值显著升高。在运动前后，二肽组的总抗氧化剂和硫醇氧化还原状态均显著升高；≥0.64 表明二肽对抗氧化剂和谷胱甘肽状态有很大影响。在二肽的影响下，氧化损伤标志物 8-异前列腺素的水平没有变化。相比之下，在二肽组中，在运动后的恢复期发现 C-反应蛋白水平降低，这表明二肽具有抗炎特性。高运动前二肽摄入增强了抗氧化状态，从而降低了剧烈运动后的氧化炎症反应。因此，二肽的应用似乎对调节剧烈运动后活跃个体的氧化应激和炎症具有有利的潜力。
