Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
Obes Surg. 2011 Sep;21(9):1438-43. doi: 10.1007/s11695-010-0277-x.
Sleeve gastrectomy (SG) has been used for the surgical treatment of morbid obesity as a first or definitive procedure with satisfactory results. The objective of this study in rats was to establish the effects of SG on weight loss depending on the post-surgical type of diet followed.
Thirty male Wistar rats were fed ad libitum during 3 months on a high-fat diet (HFD) to induce obesity. After this first phase, rats were subdivided in three groups of ten rats each and underwent a sham intervention, an SG, or no surgery but were pair-fed to the amount of food eaten by the animals of the SG group. At this time point, half of the animals in each group continued to be fed on the HFD, while the other half was switched to a normal chow diet (ND). Thus, the following subgroups were established: sham-ND, sleeve-ND, pair-fed-ND as well as sham-HFD, sleeve-HFD, and pair-fed-HFD. Body weight and food intake were recorded daily for 4 weeks. The feed efficiency rate (FER) was determined from weekly weight gains and caloric consumption during this period.
Statistically significant (P < 0.05) differences in body weight were observed between the six experimental groups after 4 weeks of the interventions with rats in the sleeve-ND group experimenting the highest weight loss (-78.2 ± 10.3 g) and animals in the pair-fed-HFD group exhibiting the lowest weight reduction (-4.0 ± 0.1 g). Interestingly, the FER value of rats that underwent the SG and continued to be fed on a HFD was significantly (P < 0.05) lower than that of sham operated and pair-fed animals on the same diet.
The positive effects of SG on weight reduction are observed in obese rats submitted to the intervention and subsequently following an ND or even an HFD.
袖状胃切除术（SG）已被用于肥胖症的外科治疗，作为一种首选或确定性手术，具有令人满意的效果。本研究旨在观察大鼠接受袖状胃切除术后，根据术后饮食类型的不同，对体重减轻的影响。
30 只雄性 Wistar 大鼠在 3 个月内自由进食高脂肪饮食（HFD），以诱导肥胖。在这一阶段之后，大鼠被分为三组，每组 10 只，分别进行假手术、SG 或不手术，但按 SG 组动物的进食量进行配对喂养。此时，每组中的一半动物继续喂食 HFD，而另一半则转换为正常的标准饲料（ND）。因此，建立了以下亚组：假手术-ND、袖状胃切除-ND、配对喂养-ND 以及假手术-HFD、袖状胃切除-HFD、配对喂养-HFD。每天记录体重和食物摄入量，持续 4 周。在此期间，通过每周体重增加和卡路里消耗来确定饲料效率比（FER）。
干预 4 周后，六组实验大鼠的体重差异有统计学意义（P<0.05），其中袖状胃切除-ND 组大鼠体重减轻最多（-78.2±10.3g），配对喂养-HFD 组大鼠体重减轻最少（-4.0±0.1g）。有趣的是，接受 SG 并继续喂食 HFD 的大鼠的 FER 值明显低于接受相同饮食的假手术和配对喂养大鼠（P<0.05）。
SG 对肥胖大鼠的减重效果是积极的，这些大鼠在接受干预后继续喂食 ND 甚至 HFD。
