Rossell Joana, González Marta, Mestres Núria, Pardina Eva, Ricart-Jané David, Peinado-Onsurbe Julia, Baena-Fustegueras Juan Antonio
Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028, Barcelona, Spain.
Unitat de Cirurgia, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, Lleida, Spain.
Obes Surg. 2017 Oct;27(10):2566-2574. doi: 10.1007/s11695-017-2650-5.
Bariatric surgery with or without diet change has become one of the most effective treatments for obesity. The objective of this study was to observe the effects of vertical sleeve gastrectomy (VSG) and diet change in Sprague-Dawley rats on both body and tissue weights.
Eighteen rats were fed with a standard chow diet (SCD) (C group), and 36 rats were fed with a high-fat diet (HFD) (diet-induced obesity (DIO) group). After 8 weeks, the animals underwent VSG, sham surgery or no surgery (NS). After surgery, a third of the rats fed with the HFD changed to the SCD (DIO + C group). Body weight, food and energy intake were recorded daily during the experiment (12 weeks). Food efficiency (%) (FE) was determined from weekly weight gain and weekly kilocalorie consumed measurements.
The DIO group had higher and significant weight gain than the C group at the time of surgery (p < 0.001). The major weight loss (WL) was observed in the DIO + C-VSG group, during the 4 weeks after surgery. Adipose tissues in the DIO + C-VSG group were drastically reduced and had a weight similar to those in the C-VSG group.
VSG and the diet change combination led to a greater WL, which was maintained during the 4 weeks post-surgery, leading to a normalization of body weight. VSG and diet change also affected most of the tissues, not only adipose, showing a global change in whole body composition.
无论是否改变饮食，减肥手术已成为治疗肥胖症最有效的方法之一。本研究的目的是观察垂直袖状胃切除术（VSG）和饮食改变对Sprague-Dawley大鼠体重和组织重量的影响。
18只大鼠喂食标准饲料（SCD）（C组），36只大鼠喂食高脂饮食（HFD）（饮食诱导肥胖（DIO）组）。8周后，动物接受VSG、假手术或不手术（NS）。手术后，三分之一喂食HFD的大鼠改为喂食SCD（DIO + C组）。实验期间（12周）每天记录体重、食物和能量摄入量。根据每周体重增加量和每周消耗的千卡量测定食物效率（%）（FE）。
手术时，DIO组的体重增加高于C组且差异显著（p < 0.001）。在手术后的4周内，主要体重减轻（WL）出现在DIO + C-VSG组。DIO + C-VSG组的脂肪组织大幅减少，其重量与C-VSG组相似。
VSG与饮食改变相结合导致更大的体重减轻，在手术后4周内得以维持，使体重恢复正常。VSG和饮食改变还影响了大多数组织，不仅是脂肪组织，显示出全身组成的整体变化。
