Neubert R, Partyka D, Wohlrab W, Dettlaff B, Fürst W, Taube K M
Section of Pharmacy, Martin Luther University, Halle.
Dermatol Monatsschr. 1990;176(11):711-6.
Using a multilayer membrane system and human horny layer the difference in the penetration of salicylic acid (SA) and its sodium (Na-S) and choline (Ch-S) salts from topical formulations was studied. It was found Na-S and Ch-S were markedly accumulated in the first membrane of the three layer membrane system used. In contrast, a rapid penetration into all three membranes was observed when SA was used. Similar penetration profiles were obtained in human horny layer. Hence, the use of the salts of SA appears to be more suitable for the application as keratolytic.
使用多层膜系统和人类角质层，研究了水杨酸（SA）及其钠盐（Na-S）和胆碱盐（Ch-S）在局部制剂中的渗透差异。结果发现，Na-S和Ch-S在所用三层膜系统的第一层膜中显著积累。相比之下，当使用SA时，观察到其能快速渗透到所有三层膜中。在人类角质层中也获得了类似的渗透曲线。因此，SA盐似乎更适合用作角质剥脱剂。
