Department of Craniofacial Development and MRC Centre for Transplantation, NIHR comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and Kings College, London, UK.
Expert Opin Biol Ther. 2010 Oct;10(10):1441-51. doi: 10.1517/14712598.2010.517191.
Mesenchymal stem cells are multipotent adult stem cell populations that have broad differentiation plasticity and immunosuppressive potential that render them of great importance in cell-based therapies. They are identified by in vitro characteristics based on their differentiation potential for clinical approaches while their biological properties and in vivo identities are often less understood.
Recent research carried out in the last decade on mesenchymal stem cell biology suggests that mesenchymal stem cells from various tissues reside in a perivascular location and these can be identified as pericytes that function as mural cells in microvessels.
This review covers recent progress on understanding the link between pericytes and mesenchymal stem cells discussing specific points such as response to injury and tissue-specific functions.
Despite a long and controversial history, there is a growing acceptance that perivascular cells are connected with mesenchymal stem cells, all that is really lacking is genetic evidence to show differentiation of pericytes into different cells types.
间充质干细胞是多能成体干细胞群体，具有广泛的分化可塑性和免疫抑制潜力，使其在基于细胞的治疗中具有重要意义。它们通过体外特征根据其临床方法的分化潜力来识别，而其生物学特性和体内身份通常理解较少。
过去十年中进行的关于间充质干细胞生物学的最新研究表明，来自各种组织的间充质干细胞位于血管周围位置，这些细胞可以被鉴定为周细胞，它们在微血管中作为壁细胞发挥作用。
本综述涵盖了最近在理解周细胞和间充质干细胞之间的联系方面的进展，讨论了特定的观点，如对损伤的反应和组织特异性功能。
尽管存在长期和有争议的历史，但越来越多的人接受了这样一种观点，即血管周围细胞与间充质干细胞有关，真正缺乏的只是遗传证据来表明周细胞分化为不同的细胞类型。
