INSERM I2MR-858, IFR-150, Avenue J Poulhès, BP 84225, Toulouse, France.
Free Radic Res. 2010 Oct;44(10):1125-71. doi: 10.3109/10715762.2010.498478.
Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.
脂质过氧化 (LPO) 产物在人体组织中的积累是组织和细胞功能障碍的主要原因，在衰老和大多数与年龄相关及氧化应激相关的疾病中起着重要作用。本文讨论了 LPO 在病理过程中的作用的现有证据。提供了新的数据和文献综述，评估了 LPO 在衰老的病理生理学中的作用，以及与氧化应激相关的经典疾病，如神经退行性疾病、糖尿病和动脉粥样硬化（心血管并发症的主要原因）。本文还探讨了 LPO 在子痫前期、肾脏和肝脏疾病中胎儿血管功能障碍中的作用，以及它们作为癌症发展的原因和后果的作用。
