肽YY和促胰液素对人胃酸分泌的抑制作用。

Inhibition of human gastric acid secretion by peptide YY and secretin.

作者信息

Olsen O, Christiansen J

机构信息

Department of Surgery D, Glostrup Hospital, University of Copenhagen, Denmark.

出版信息

Digestion. 1990;47(3):156-9. doi: 10.1159/000200491.

DOI:10.1159/000200491

PMID:2083801

Abstract

In 6 healthy volunteers we investigated the effect of secretin and peptide YY (PYY) on gastric acid secretion stimulated by pentagastrin (100 ng/kg/h). Secretin (0.05 CU/kg/h) and PYY (10.0 pmol/kg/h) were given intravenously either alone or in combination. Given alone secretin and PYY inhibited gastric acid output by 25 and 21%, respectively. The combined infusion of secretin and PYY inhibited acid output by 38% indicating an additive effect. The infusion of one hormone did not influence release of the other. It is suggested that the interaction of PYY and secretin on pentagastrin-stimulated gastric acid secretion in normal man is of the additive type.

摘要

在6名健康志愿者中，我们研究了促胰液素和肽YY（PYY）对五肽胃泌素（100 ng/kg/h）刺激的胃酸分泌的影响。促胰液素（0.05 CU/kg/h）和PYY（10.0 pmol/kg/h）单独或联合静脉注射。单独给予时，促胰液素和PYY分别使胃酸分泌量减少25%和21%。促胰液素和PYY联合输注使胃酸分泌量减少38%，表明存在相加作用。输注一种激素不影响另一种激素的释放。提示在正常人中，PYY和促胰液素对五肽胃泌素刺激的胃酸分泌的相互作用为相加类型。