神经降压素和胃泌酸调节素-（30-37）增强PYY对胃酸和生长抑素分泌的调节作用。

Neurotensin and oxyntomodulin-(30-37) potentiate PYY regulation of gastric acid and somatostatin secretions.

作者信息

Bado A, Cloarec D, Moizo L, Laigneau J P, Bataille D, Lewin M J

机构信息

Institut National de la Santé et de la Recherche Médicale Unité de Gastroentérologie U10, Hôpital Bichat, Paris, France.

出版信息

Am J Physiol. 1993 Jul;265(1 Pt 1):G113-7. doi: 10.1152/ajpgi.1993.265.1.G113.

DOI:10.1152/ajpgi.1993.265.1.G113

PMID:8101697

Abstract

The present study was designed to investigate, in cats provided with both a gastric fistula and a denervated fundic Heidenhain pouch, the effect of peptide YY (PYY) on pentagastrin-stimulated gastric acid and somatostatin secretions and to determine whether neurotensin (NT) and the COOH-terminal octapeptide of oxyntomodulin [Oxm-(30-37)] would modify these secretions. Intravenous infusion of PYY (0.1 nmol.kg-1.h-1), NT (15 nmol.kg-1.h-1), or Oxm-(30-37) (60 nmol.kg-1.h-1) did not affect basal acid secretion. However, they significantly inhibited pentagastrin-stimulated gastric acid output up to 50% (P < 0.01) in the main stomach. Furthermore, they significantly increased gastric somatostatin release by +750, +1,700, and +600% over basal level (P < 0.01) for (in nmol.kg-1.h-1) 0.1 PYY, 15 NT, and 60 Oxm-(30-37), respectively. On the other hand, the effects of 0.1 nmol.kg-1.h-1 PYY were potentiated by subthreshold doses of NT (5 nmol.kg-1.h-1) or Oxm-(30-37) (15 nmol.kg-1.h-1). These findings suggest that there could be a cooperation between the three peptides in the intestinal regulation of gastric secretions.

摘要

本研究旨在探讨在同时具备胃瘘和去神经支配的海登海因胃体袋的猫中，肽YY（PYY）对五肽胃泌素刺激的胃酸和生长抑素分泌的影响，并确定神经降压素（NT）和胃动素羧基末端八肽[Oxm-(30-37)]是否会改变这些分泌。静脉输注PYY（0.1 nmol·kg-1·h-1）、NT（15 nmol·kg-1·h-1）或Oxm-(30-37)（60 nmol·kg-1·h-1）对基础胃酸分泌无影响。然而，它们可显著抑制五肽胃泌素刺激的主胃胃酸分泌，抑制率高达50%（P < 0.01）。此外，它们可使胃生长抑素释放量分别比基础水平显著增加+750%、+1700%和+600%（P < 0.01），分别对应（以nmol·kg-1·h-1计）0.1 PYY、15 NT和60 Oxm-(30-37)。另一方面，亚阈值剂量的NT（5 nmol·kg-1·h-1）或Oxm-(30-37)（15 nmol·kg-1·h-1）可增强0.1 nmol·kg-1·h-1 PYY的作用。这些发现表明，这三种肽在胃分泌的肠道调节中可能存在协同作用。