克罗恩病患者血清中针对厌氧肠道菌群肽聚糖 - 多糖复合物的抗体
Serum antibodies to peptidoglycan-polysaccharide complexes from the anaerobic intestinal flora in patients with Crohn's disease.
作者信息
Hazenberg M P, de Visser H, Bras M J, Prins M E, van de Merwe J P
机构信息
Department of Immunology, Erasmus University Rotterdam, The Netherlands.
出版信息
Digestion. 1990;47(3):172-80. doi: 10.1159/000200494.
Soluble peptidoglycan-polysaccharide complexes (PPC) isolated from feces of a healthy subject shared antigens with 22 out of 40 anaerobic intestinal bacteria and, therefore, these could be considered as flora derived. IgG, IgA and IgM antibodies against PPC were found in sera from healthy subjects, patients with Crohn's disease (CD) and other patients. In sera of CD patients with agglutinating antibodies to 4 anaerobic intestinal bacteria (used as an aid for diagnosis of CD) IgG and IgA levels to PPC were higher than in CD patients without these antibodies.
从一名健康受试者粪便中分离出的可溶性肽聚糖-多糖复合物（PPC）与40种厌氧肠道细菌中的22种存在共同抗原，因此，这些复合物可被视为源自肠道菌群。在健康受试者、克罗恩病（CD）患者及其他患者的血清中均发现了针对PPC的IgG、IgA和IgM抗体。在对4种厌氧肠道细菌有凝集抗体（用于辅助诊断CD）的CD患者血清中，针对PPC的IgG和IgA水平高于无这些抗体的CD患者。
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