抗去唾液酸GM1抑制痘苗病毒对小鼠卵巢的感染：去唾液酸GM1作为一种额外的病毒受体？
Anti-asialo-GM1 inhibits vaccinia virus infection of murine ovaries: asialo-GM1 as an additional virus receptor?
作者信息
Karupiah G, Blanden R V
机构信息
Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT.
出版信息
Immunol Cell Biol. 1990 Oct;68 ( Pt 5):343-6. doi: 10.1038/icb.1990.46.
The neurovirulent strain of vaccinia virus, VV-WR, or recombinants derived from VV-WR, cause highly productive infection of murine ovaries, but infection could be partially inhibited in vivo using an antiserum to asialo-GM1 (as-GM1). In vitro analysis by flow cytometry revealed that murine ovarian cells expressed a cell surface antigen identical to or cross-reactive with as-GM1. The capacity of VV-WR to infect murine ovaries appears to depend in part upon as-GM1 expression on ovarian cells.
痘苗病毒的神经毒力株VV-WR，或源自VV-WR的重组体，可引起小鼠卵巢的高效感染，但使用抗脱唾液酸GM1（as-GM1）抗血清可在体内部分抑制感染。通过流式细胞术进行的体外分析显示，小鼠卵巢细胞表达一种与as-GM1相同或交叉反应的细胞表面抗原。VV-WR感染小鼠卵巢的能力似乎部分取决于卵巢细胞上as-GM1的表达。
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