利用气相色谱-质谱联用技术分析葱莲中的石蒜科生物碱及其胆碱酯酶活性
Analysis of Amaryllidaceae alkaloids from Zephyranthes robusta by GC-MS and their cholinesterase activity.
作者信息
Cahlíková Lucie, Kulhánková Andrea, Urbanová Klára, Valterová Irena, Macáková Katerina, Kunes Jirí
机构信息
Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
出版信息
Nat Prod Commun. 2010 Aug;5(8):1201-4.
From the bulbs of Zephyranthes robusta Baker (Amaryllidaceae), seven known compounds, belonging to four structural types of Amaryllidaceae alkaloids, were identified and quantified by GC-MS. The alkaloid extract from the bulbs showed promising acetylcholinesterase and butyrylcholinesterase inhibitory activities against HuAChE (IC50 = 35.9 +/- 3.5 microg/mL) and HuBuChE (IC50 = 190.9 +/- 8.2 microg/mL).
从葱莲（石蒜科）的鳞茎中，通过气相色谱 - 质谱联用仪鉴定并定量了七种已知化合物，它们属于石蒜科生物碱的四种结构类型。鳞茎中的生物碱提取物对人乙酰胆碱酯酶（IC50 = 35.9 +/- 3.5微克/毫升）和人丁酰胆碱酯酶（IC50 = 190.9 +/- 8.2微克/毫升）显示出有前景的乙酰胆碱酯酶和丁酰胆碱酯酶抑制活性。
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