9-O-去甲基加兰他敏的修订核磁共振数据：一种来自强健葱莲（石蒜科）的生物碱及其生物活性。

Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological activity.

作者信息

Safratová Marcela, Novák Zdenek, Kulhánková Andrea, Kunes Jirí, Hrabinová Martina, Jun Daniel, Macáková Katerina, Opletal Lubomír, Cahlíková Lucie

出版信息

Nat Prod Commun. 2014 Jun;9(6):787-8.

PMID:25115079

Abstract

Ongoing studies of Zephyranthes robusta resulted in the isolation of the lycorine-type alkaloid previously called carinatine and 10-O-demethylgalanthine. The NMR data given previously for this compound were revised and completed by two-dimensional 1H-1H and 1H-13C chemical shift correlation experiments. The name of the isolated compound was corrected to 9-O-demethylgalanthine in accordance with the currently used system of numbering of lycorine-type alkaloids. 9-O-Demethylgalanthine and galanthine, a previously isolated alkaloid from Z robusta, were inactive in acetylcholinesterase/butyrylcholinesterase assays (IC50 > 500 microM), but showed important prolyl oligopeptidase inhibition activity.

摘要

对葱莲的持续研究导致分离出了以前称为卡瑞亭的石蒜碱型生物碱和10-O-去甲基加兰他敏。通过二维1H-1H和1H-13C化学位移相关实验对该化合物先前给出的核磁共振数据进行了修订和完善。根据目前使用的石蒜碱型生物碱编号系统，将分离出的化合物名称更正为9-O-去甲基加兰他敏。9-O-去甲基加兰他敏和加兰他敏（一种先前从葱莲中分离出的生物碱）在乙酰胆碱酯酶/丁酰胆碱酯酶测定中无活性（IC50>500 microM），但显示出重要的脯氨酰寡肽酶抑制活性。