Radcliffe Nathan M, Sehi Mitra, Wallace Ira B, Greenfield David S, Krupin Theodore, Ritch Robert
Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY, USA.
Ophthalmic Surg Lasers Imaging. 2010 Nov-Dec;41(6):629-34. doi: 10.3928/15428877-20100830-02. Epub 2010 Aug 30.
To compare agreement of automated alternation flicker and serial stereophotograph inspection for detection of progressive glaucoma.
Serial photographs of patients with glaucoma with at least 36 months of follow-up and perimetry every 4 months were assessed by four graders using predefined criteria with both flicker and stereophotography. The main outcome measure was progressive neuroretinal rim deterioration as identified by each technique.
Forty eyes (20 patients) were included and 12 eyes progressed with perimetry. Using stereophotography, the overall agreement (kappa ± standard error) was 0.19 ± 0.06 for rim change, 0.78 ± 0.06 for disc hemorrhage, and -0.04 ± 0.06 for vessel movement. Using flicker, the overall agreement was similar for rim change (0.28 ± 0.06; P = .29), worse for disc hemorrhage (0.43 ± 0.06; P < .001), and better for vessel movement (0.22 ± 0.06; P = .002). The agreement between perimetric and disc progression was similar using stereophotography (0.10 ± 0.05) and flicker (0.19 ± 0.05; P = .20).
Agreement between flicker and stereophotography was similar.
比较自动交替闪烁检查和系列立体照相检查在检测进展性青光眼方面的一致性。
对至少随访36个月的青光眼患者的系列照片以及每4个月进行的视野检查结果，由四名分级者依据预先设定的闪烁检查和立体照相检查标准进行评估。主要观察指标是每种技术所识别的进行性神经视网膜边缘恶化情况。
纳入40只眼（20例患者），其中12只眼视野出现进展。使用立体照相检查时，边缘变化的总体一致性（kappa±标准误）为0.19±0.06，视盘出血为0.78±0.06，血管移动为-0.04±0.06。使用闪烁检查时，边缘变化的总体一致性与之相似（0.28±0.06；P = 0.29），视盘出血的一致性较差（0.43±0.06；P < 0.001），血管移动的一致性较好（0.22±0.06；P = 0.002）。使用立体照相检查时视野和视盘进展之间的一致性为0.10±0.05，使用闪烁检查时为0.19±0.05（P = 0.20）。
闪烁检查和立体照相检查之间的一致性相似。
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