MIRA Institute for Biomedical Technology and Technical Medicine and Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.
Biomacromolecules. 2010 Oct 11;11(10):2692-9. doi: 10.1021/bm1007234.
Biodegradable elastomeric poly(trimethylene carbonate) (PTMC) networks were efficiently formed by gamma irradiating the linear polymer in the presence of pentaerythritol triacrylate (PETA). The properties of networks formed upon irradiation of PTMC films containing (0, 1, 5 wt %) PETA as a cross-linking aid were evaluated. The gel contents and network densities increased with increasing PETA contents, irradiation dose, and initial polymer molecular weights. At a dose of 25 kGy, networks with gel fractions up to 0.96 could be obtained. The networks were noncytotoxic, had elastic moduli below 10.7 MPa and high tensile strengths of up to 37.7 MPa. The incorporation of PETA also improved the resistance to creep and to tear propagation significantly, resulting in permanent set values that were as low as 0.9% strain and tear strengths up to 9.3 ± 2.0 N/mm. Furthermore, the enzymatic erosion rates of the networks could be decreased from 12.0 ± 2.9 to 3.0 ± 1.6 μm/day. These biodegradable elastomeric PTMC networks may be utilized in a broad range of medical applications.
可生物降解的弹性聚（三亚甲基碳酸酯）（PTMC）网络可以通过在存在季戊四醇三丙烯酸酯（PETA）的情况下辐照线性聚合物来有效地形成。评估了作为交联助剂的含有（0、1、5wt%）PETA 的 PTMC 薄膜在辐照下形成的网络的性质。凝胶含量和网络密度随 PETA 含量、辐照剂量和初始聚合物分子量的增加而增加。在 25kGy 的剂量下，可以获得凝胶分数高达 0.96 的网络。这些网络是非细胞毒性的，弹性模量低于 10.7MPa，拉伸强度高达 37.7MPa。PETA 的掺入还显著提高了抗蠕变和撕裂扩展的能力，导致永久变形值低至 0.9%应变和高达 9.3±2.0N/mm 的撕裂强度。此外，网络的酶侵蚀速率可以从 12.0±2.9μm/天降低到 3.0±1.6μm/天。这些可生物降解的弹性 PTMC 网络可用于广泛的医疗应用。
