Friedman G D, Tekawa I, Grimm R H, Manolio T, Shannon S G, Sidney S
Division of Research, Kaiser Permanente Medical Care Program, Oakland, California.
Int J Epidemiol. 1990 Dec;19(4):889-93. doi: 10.1093/ije/19.4.889.
Correlates of the leucocyte count (WBC) and its relationships to other coronary heart disease (CHD) risk factors were assessed in 4981 black and white young adults. Mean WBC was higher in women than men, higher in whites than blacks, and higher in those aged 18-24 than aged 25-30 years. It also varied by season with the highest levels in the autumn. Other characteristics with persistent statistically significant direct associations with the WBC after multivariate adjustments were cigarette smoking, marijuana use, geographical location (possibly an inter-laboratory artifact), use of birth control pills, body mass index, pulse rate, and systolic blood pressure; height, physical fitness and high density lipoprotein cholesterol (HDL-C) level were inversely associated with the WBC. The negative association of WBC with HDL-C was too small to explain the association of WBC with CHD found elsewhere. The WBC is a commonly performed clinical test; yet much remains to be learned about its variation in the general population and its value as a predictor rather than merely an indicator of disease.
在4981名黑人和白人青年中评估了白细胞计数（WBC）的相关因素及其与其他冠心病（CHD）危险因素的关系。女性的平均白细胞计数高于男性，白人高于黑人，18 - 24岁人群高于25 - 30岁人群。白细胞计数也随季节变化，秋季水平最高。多变量调整后，与白细胞计数存在持续统计学显著直接关联的其他特征包括吸烟、使用大麻、地理位置（可能是实验室间的假象）、使用避孕药、体重指数、脉搏率和收缩压；身高、身体素质和高密度脂蛋白胆固醇（HDL-C）水平与白细胞计数呈负相关。白细胞计数与HDL-C的负相关太小，无法解释在其他地方发现的白细胞计数与冠心病的关联。白细胞计数是一项常用的临床检查；然而，关于其在一般人群中的变化及其作为疾病预测指标而非仅仅是疾病指标的价值，仍有许多有待了解之处。
