Weijenberg M P, Feskens E J, Kromhout D
Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):499-503. doi: 10.1161/01.atv.16.4.499.
Because the importance of established risk factors for coronary heart disease (CHD) is unclear in older people, the associations of white blood cell (WBC) count with the risk for CHD and all-cause mortality were investigated in an elderly cohort that was followed up for 5 years. In 1985, complete information on the risk factors of interest was available for 884 randomly selected men, aged 64 to 84 years, from the Dutch town of Zutphen (participation rate, 74%). Relative risks (RRs) for each 10(9)/L increase in WBC count were obtained for the 5-year incidence of and mortality from CHD and all causes. RRs were adjusted for age, body mass index, systolic blood pressure, total and high density lipoprotein cholesterol levels, and cigarette smoking habit. The WBC count was 6.7 +/- 1.8 X 10(9)/L (means +/- SD) at baseline. An increased WBC count was independently associated with mortality due to CHD, and the RR amounted to 1.32 (95% confidence interval [95% CI], 1.15 to 1.51). For the incidence of CHD the RR was 1.14 (95% CI, 0.98 to 1.32). These associations were observed regardless of cigarette smoking habit. Regarding all-cause mortality, the RR amounted to 1.25 (95% CI, 1.17 to 1.35). This association was especially noticeable among former smokers and those who had never smoked. In conclusion, during 5 years of follow-up WBC count predicted CHD and all-cause mortality in elderly men, independent of the conventional risk factors for CHD.
由于已确定的冠心病（CHD）危险因素在老年人中的重要性尚不清楚，因此在一个随访了5年的老年队列中，研究了白细胞（WBC）计数与冠心病风险及全因死亡率之间的关联。1985年，从荷兰祖特芬镇随机选取了884名年龄在64至84岁之间的男性，获取了他们关于感兴趣的危险因素的完整信息（参与率为74%）。计算了白细胞计数每增加10⁹/L时，冠心病和全因导致的5年发病率及死亡率的相对风险（RRs）。RRs针对年龄、体重指数、收缩压、总胆固醇和高密度脂蛋白胆固醇水平以及吸烟习惯进行了调整。基线时白细胞计数为6.7±1.8×10⁹/L（均值±标准差）。白细胞计数升高与冠心病导致的死亡率独立相关，RR为1.32（95%置信区间[95%CI]，1.15至1.51）。冠心病发病率的RR为1.14（95%CI，0.98至1.32）。无论吸烟习惯如何，均观察到这些关联。关于全因死亡率，RR为1.25（95%CI，1.17至1.35）。这种关联在既往吸烟者和从不吸烟者中尤为明显。总之，在5年的随访期间，白细胞计数可预测老年男性的冠心病和全因死亡率，且独立于冠心病的传统危险因素。
