Department of Dermatology School of Medicine, The George Washington University Medical Center, Washington, DC, USA.
J Eur Acad Dermatol Venereol. 2011 Apr;25(4):383-91. doi: 10.1111/j.1468-3083.2010.03841.x. Epub 2010 Sep 14.
Several recent studies have found an increased prevalence of non-alcoholic fatty liver disease within psoriasis patients. The exact pathophysiological mechanisms behind these observations are unclear, but are likely related to the high prevalence of obesity and metabolic syndrome within this patient population. Chronic inflammation, mediated by either proinflammatory adipokines or skin-derived cytokines, may contribute to fatty liver disease development by increasing insulin resistance which in turn promotes hepatic lipid accumulation. These same adipokines in addition to hepatic cytokines may act on the skin to influence psoriasis disease severity.
几项最近的研究发现，银屑病患者中非酒精性脂肪性肝病的患病率有所增加。这些观察结果背后的确切病理生理机制尚不清楚，但可能与该患者人群中肥胖症和代谢综合征的高患病率有关。慢性炎症可由促炎脂肪因子或皮肤来源的细胞因子介导，通过增加胰岛素抵抗进而促进肝脂质积聚，从而促进脂肪肝的发展。这些相同的脂肪因子以及肝细胞因子可能作用于皮肤，影响银屑病的严重程度。
