Bush R K, Smith A M, Welling P G, Alcala J C, Lee T P
Ann Allergy. 1978 Jul;41(1):13-7.
In a single-blind, crossover study 10 adult asthmatic patients received a theophylline-ephedrine combination tablet (theophylline 90 mg, ephedrine 16 mg and phenobarbital 25 mg in an immediate release layer and theophylline 90 mg and ephedrine 32 mg in a sustained release layer) twice daily or terbutaline 5 mg three times daily for two weeks. There was no significant difference in bronchodilator response to a single dose of the study drugs on either the initial day of treatment or after two weeks of continuous therapy. Mean increases in serum cyclic-AMP levels produced by both drugs were not significantly different. Mean peak plasma theophylline levels were 2.9 +/- 1.3 microgram/ml following the initial dose and 7.3 +/- 3.4 microgram/ml after two weeks of continuous dosing with the combination drug. No adverse effects on blood pressure or pulse rate were observed to either drug. Overall, the incidence and severity of reported side effects (tremor, nausea and nervousness) were less with the theophylline-ephedrine combination.
在一项单盲交叉研究中，10名成年哮喘患者每日两次服用氨茶碱 - 麻黄碱复方片剂（速释层含氨茶碱90毫克、麻黄碱16毫克和苯巴比妥25毫克，缓释层含氨茶碱90毫克和麻黄碱32毫克）或每日三次服用特布他林5毫克，持续两周。在治疗首日或持续治疗两周后，对单剂量研究药物的支气管扩张反应无显著差异。两种药物引起的血清环磷酸腺苷水平的平均升高无显著差异。初始剂量后氨茶碱的平均血浆峰值水平为2.9±1.3微克/毫升，联合用药持续给药两周后为7.3±3.4微克/毫升。两种药物均未观察到对血压或脉搏率有不良影响。总体而言，氨茶碱 - 麻黄碱复方制剂报告的副作用（震颤、恶心和紧张）的发生率和严重程度较低。
