van der Vet A P, Kreukniet J, van Drost R H, Maes R A, Fokkens J K, Hamelink M J
Department of Pulmonology, University Hospital Maastricht, University of Limburg, The Netherlands.
Int J Clin Pharmacol Ther Toxicol. 1987 Oct;25(10):558-64.
In a group of ten patients with chronic asthmatic bronchitis, the effect of monotherapy with theophylline and terbutaline and the combination of both drugs, as sustained-release tablets, was compared to placebo, in a double-blind cross-over, triple dummy at random study. Lung function parameters, tremor measurements, c-AMP plasma levels, theophylline- and terbutaline-plasma levels were determinated. Monotherapy with theophylline and terbutaline in a relatively low dosage achieved a good lung function improvement without severe side effects, as compared to placebo. The combination of both drugs in the same dosage achieved a statistically significant enhancement of the lung function improvement, as compared to monotherapy, without an increase of side effects. An additional effect of theophylline and terbutaline on bronchodilation is demonstrated.
在一组10名慢性哮喘性支气管炎患者中，采用双盲交叉、三模拟随机研究，将茶碱和特布他林单药治疗及两种药物联合制成缓释片的效果与安慰剂进行了比较。测定了肺功能参数、震颤测量值、血浆环磷酸腺苷（c-AMP）水平、茶碱和特布他林血浆水平。与安慰剂相比，相对低剂量的茶碱和特布他林单药治疗在无严重副作用的情况下实现了良好的肺功能改善。与单药治疗相比，相同剂量的两种药物联合使用在肺功能改善方面有统计学显著增强，且副作用未增加。证明了茶碱和特布他林对支气管扩张有额外作用。
