Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
J Periodontol. 2011 Mar;82(3):388-94. doi: 10.1902/jop.2010.100336. Epub 2010 Sep 15.
As the periodontal tissues mount an immune inflammatory response to bacteria and their products, the systemic challenge with these agents also induces a major vascular response. Certain inflammatory cytokines produced during periodontal inflammation can depress erythropoietin production leading to the development of anemia. The aim of this study is to investigate whether patients with chronic periodontitis have an anemic status, and subsequently, to analyze the effect of non-surgical periodontal therapy on the anemic status of subjects over a 6-month period.
A total of 187 patients with chronic periodontitis participated in the study. After red blood cell analyses, 60 patients with hemoglobin concentrations below reference ranges entered into the second part of the study in which patients were treated with non-surgical periodontal therapy. Clinical parameters and red blood cell analyses were repeated at 3 and 6 months.
In the first part of the study, 33.6% of patients had hemoglobin concentrations below normal reference ranges. In the second part of the study, all red blood cell parameters and clinical parameters showed statistical improvements over a 6-month period.
The present study strengthens the hypothesis that chronic periodontitis may lead to anemia and provides evidence that non-surgical periodontal therapy can improve the anemic status of patients with chronic periodontitis with greater improvement in females.
当牙周组织对细菌及其产物产生免疫炎症反应时，这些病原体对全身系统的挑战也会引起主要的血管反应。牙周炎期间产生的某些炎症细胞因子可能会抑制促红细胞生成素的产生，导致贫血的发生。本研究旨在探讨慢性牙周炎患者是否存在贫血状态，随后分析非手术性牙周治疗对受试者在 6 个月内贫血状态的影响。
共有 187 名慢性牙周炎患者参与了这项研究。在进行红细胞分析后，60 名血红蛋白浓度低于参考范围的患者进入研究的第二部分，这些患者接受了非手术性牙周治疗。在 3 个月和 6 个月时重复进行临床参数和红细胞分析。
在研究的第一部分，33.6%的患者血红蛋白浓度低于正常参考范围。在研究的第二部分，所有红细胞参数和临床参数在 6 个月内均显示出统计学上的改善。
本研究进一步证实了慢性牙周炎可能导致贫血的假设，并提供了证据表明，非手术性牙周治疗可以改善慢性牙周炎患者的贫血状态，女性患者的改善更为明显。
