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通过血液参数评估贫血与牙周炎之间的关系：一项横断面研究。

Evaluation of the relation between anemia and periodontitis by estimation of blood parameters: A cross-sectional study.

作者信息

Anumolu Venkata Naga Sri Harsha, Srikanth Adusumilli, Paidi Kusumalatha

机构信息

Department of Periodontics and Implantology, Dr. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Chinnaoutpalli, Gannavaram Mandal, Krishna, Andhra Pradesh, India.

出版信息

J Indian Soc Periodontol. 2016 May-Jun;20(3):265-72. doi: 10.4103/0972-124X.176392.

DOI:10.4103/0972-124X.176392
PMID:27563199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4976546/
Abstract

BACKGROUND

Anemia of chronic disease is defined as anemia occurring in chronic infections, inflammatory conditions, or neoplastic disorders which are not due to marrow deficiencies or other diseases, and occurring despite the presence of adequate iron stores and vitamins.

AIMS

To evaluate the relation between anemia and periodontitis by estimation of blood parameters and to assess whether periodontitis like other inflammatory conditions can lead to anemia. It is a randomized controlled clinical trial.

MATERIALS AND METHODS

A total of 50 healthy controls, 50 chronic generalized gingivitis, and 50 chronic generalized periodontitis patients were selected. Hemoglobin levels (Hb), erythrocyte count red blood cell, erythrocyte sedimentation rate (ESR), mean corpuscular volu e (MCV), mean corpuscular Hb (MCH) and MCH concentration (MCHC), gingival index, plaque index, probing pocket depth, and clinical attachment level were recorded. Intergroup comparison of blood parameters is by one-way ANOVA. Intergroup pair wise comparison of the three groups is by Newman-Keuls multiple post-hoc procedures. Karl Pearsons's correlation coefficient method is used for correlation between different parameters for three groups.

RESULTS

The results revealed a decrease in Hb and erythrocyte counts and increase in white blood corpuscles counts in chronic generalized periodontitis when compared to healthy controls and chronic generalized gingivitis group. There was no statistically significant difference in MCV, MCH, MCHC, and ESR among the groups.

CONCLUSIONS

The treatment of periodontitis can lead to an improvement in hematocrit and other related blood parameters in chronic generalized periodontitis patients with anemia. This provides evidence that periodontitis like other chronic diseases may also cause anemia.

摘要

背景

慢性病性贫血被定义为发生在慢性感染、炎症性疾病或肿瘤性疾病中的贫血，并非由于骨髓缺乏或其他疾病引起，且尽管存在充足的铁储备和维生素仍会发生。

目的

通过评估血液参数来评估贫血与牙周炎之间的关系，并评估牙周炎是否像其他炎症性疾病一样会导致贫血。这是一项随机对照临床试验。

材料与方法

共选取50名健康对照者、50名慢性广泛性牙龈炎患者和50名慢性广泛性牙周炎患者。记录血红蛋白水平（Hb）、红细胞计数、红细胞沉降率（ESR）、平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）和平均红细胞血红蛋白浓度（MCHC）、牙龈指数、菌斑指数、探诊深度和临床附着水平。血液参数的组间比较采用单因素方差分析。三组间的组间两两比较采用纽曼-柯尔斯多重事后检验程序。采用卡尔·皮尔逊相关系数法分析三组不同参数之间的相关性。

结果

结果显示，与健康对照组和慢性广泛性牙龈炎组相比，慢性广泛性牙周炎患者的Hb和红细胞计数降低，白细胞计数升高。各组间的MCV、MCH、MCHC和ESR无统计学显著差异。

结论

牙周炎的治疗可使慢性广泛性牙周炎贫血患者的血细胞比容和其他相关血液参数得到改善。这提供了证据表明牙周炎像其他慢性疾病一样也可能导致贫血。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/16025a48f8db/JISP-20-265-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/90dbe27c556b/JISP-20-265-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/2903c9cdeb1c/JISP-20-265-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/a578c8ed89c6/JISP-20-265-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/bea8915ca30e/JISP-20-265-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/f4321641bc3a/JISP-20-265-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/2cb3ee0e1e26/JISP-20-265-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/5285e7ccd765/JISP-20-265-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/16025a48f8db/JISP-20-265-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/90dbe27c556b/JISP-20-265-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/2903c9cdeb1c/JISP-20-265-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/a578c8ed89c6/JISP-20-265-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/bea8915ca30e/JISP-20-265-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/f4321641bc3a/JISP-20-265-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/2cb3ee0e1e26/JISP-20-265-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/5285e7ccd765/JISP-20-265-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c87/4976546/16025a48f8db/JISP-20-265-g019.jpg

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