Walter Reed Army Institute of Research, Preventive Medicine Residency Program, Silver Spring, Maryland 20910, USA.
Int J Tuberc Lung Dis. 2010 Oct;14(10):1310-5.
Despite the low incidence of tuberculosis (TB) in the United States military, there is uncertainty in the overall reporting and estimates of incidence.
To assess TB reporting in the active component US military.
TB notification in the US military was compared with three other data sources: laboratory, hospitalization and pharmacy records. Sensitivity and positive predictive value were estimated for all data sources using a gold standard of either a reportable medical event (RME) reported as confirmed or a positive laboratory result for Mycobacterium tuberculosis. Uncorrected and capture-recapture (CR) methods were used to estimate underreporting and completeness of data sources.
Completeness of reporting of pulmonary TB cases was estimated as 72.4% uncorrected or 58.3% with CR. Even after correction for possible underreporting, the incidence of active pulmonary TB was only 0.87 per 100,000 person-years between 2004 and 2006.
The rate of active TB in the US military is low. Like civilian surveillance, US military RME surveillance may substantially underreport TB incidence rates. Expanding surveillance to include data sources such as hospitalizations and pharmacy records will increase the number of TB diagnoses at the cost of including many false-positives.
尽管美国军队中结核病(TB)的发病率较低,但在总报告和发病率估计方面仍存在不确定性。
评估美国现役军人中的结核病报告情况。
将美国军队中的结核病通知与另外三个数据源进行比较:实验室、住院和药房记录。使用报告的医疗事件(RME)报告为确诊或分枝杆菌结核阳性实验室结果的金标准,分别估计所有数据源的敏感性和阳性预测值。使用未校正和捕获-再捕获(CR)方法来估计数据源的漏报和完整性。
未校正时,肺结案例的报告完整性估计为 72.4%,CR 时为 58.3%。即使在对可能的漏报进行校正后,2004 年至 2006 年期间,现役肺结案例的发病率也仅为每 100,000 人年 0.87 例。
美国军队中的结核病发病率较低。与平民监测一样,美国军队的 RME 监测可能会大大低估结核病发病率。扩大监测范围,纳入住院和药房记录等数据源,将增加结核病诊断数量,但代价是包括许多假阳性。