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Relationship between surface accessibility for PpmA, PsaA, and PspA and antibody-mediated immunity to systemic infection by Streptococcus pneumoniae.肺炎链球菌表面蛋白A(PpmA)、表面蛋白A(PsaA)和表面蛋白A(PspA)的表面可及性与抗体介导的全身性感染免疫之间的关系。
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Generation and Improvement of Effector Function of a Novel Broadly Reactive and Protective Monoclonal Antibody against Pneumococcal Surface Protein A of Streptococcus pneumoniae.一种新型的针对肺炎链球菌肺炎球菌表面蛋白A的广泛反应性和保护性单克隆抗体的效应功能的产生与改进
PLoS One. 2016 May 12;11(5):e0154616. doi: 10.1371/journal.pone.0154616. eCollection 2016.
2
Immunoactivating peptide p4 augments alveolar macrophage phagocytosis in two diverse human populations.免疫激活肽 p4 增强了两个不同人群肺泡巨噬细胞的吞噬作用。
Antimicrob Agents Chemother. 2013 Sep;57(9):4566-9. doi: 10.1128/AAC.00742-13. Epub 2013 Jul 1.
3
A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia.一种与静脉注射免疫球蛋白相结合的新型先天免疫增强策略可使小鼠从致命的金黄色葡萄球菌败血症中获救。
Int J Microbiol. 2011;2011:725483. doi: 10.1155/2011/725483. Epub 2011 Nov 16.

本文引用的文献

1
An augmented passive immune therapy to treat fulminant bacterial infections.一种用于治疗暴发性细菌感染的增强型被动免疫疗法。
Recent Pat Antiinfect Drug Discov. 2010 Jun;5(2):157-67. doi: 10.2174/157489110791233496.
2
Neutrophils promote inflammatory angiogenesis via release of preformed VEGF in an in vivo corneal model.中性粒细胞通过在体内角膜模型中释放预先形成的 VEGF 促进炎症性血管生成。
Cell Tissue Res. 2010 Feb;339(2):437-48. doi: 10.1007/s00441-009-0908-5. Epub 2009 Dec 12.
3
Aged mice display an altered pulmonary host response to Francisella tularensis live vaccine strain (LVS) infections.老年小鼠对土拉弗朗西斯菌活疫苗株(LVS)感染的肺部宿主反应发生改变。
Exp Gerontol. 2010 Feb;45(2):91-6. doi: 10.1016/j.exger.2009.10.004. Epub 2009 Oct 13.
4
Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia.与年龄相关的炎症和Toll样受体功能障碍使肺部易患肺炎球菌肺炎。
J Infect Dis. 2009 Aug 15;200(4):546-54. doi: 10.1086/600870.
5
Evaluation of a novel therapeutic approach to treating severe pneumococcal infection using a mouse model.使用小鼠模型评估一种治疗严重肺炎球菌感染的新型治疗方法。
Clin Vaccine Immunol. 2009 Jun;16(6):806-10. doi: 10.1128/CVI.00120-09. Epub 2009 Apr 22.
6
A 28-aa pneumococcal surface adhesin A-derived peptide, P4, augments passive immunotherapy and rescues mice from fatal pneumococcal infection.一种由28个氨基酸组成的肺炎球菌表面黏附素A衍生肽P4可增强被动免疫疗法,并使小鼠从致命的肺炎球菌感染中获救。
J Infect Dis. 2009 Apr 15;199(8):1233-8. doi: 10.1086/597425.
7
A functional epitope of the pneumococcal surface adhesin A activates nasopharyngeal cells and increases bacterial internalization.肺炎球菌表面黏附素A的一个功能性表位激活鼻咽细胞并增加细菌内化。
Microb Pathog. 2008 Mar;44(3):186-96. doi: 10.1016/j.micpath.2007.09.003. Epub 2007 Oct 5.
8
Immunological changes in the elderly.老年人的免疫变化。
Aging (Milano). 1999 Oct;11(5):281-6. doi: 10.1007/BF03339801.
9
The immune system in the elderly: III. Innate immunity.老年人的免疫系统:III. 固有免疫
Immunol Res. 1999;20(2):117-26. doi: 10.1007/BF02786468.
10
The immune system in the elderly: II. Specific cellular immunity.老年人的免疫系统:II. 特异性细胞免疫
Immunol Res. 1999;20(2):109-15. doi: 10.1007/BF02786467.

P4 peptide therapy rescues aged mice from fatal pneumococcal sepsis.

作者信息

Rajam Gowrisankar, Bangert Mathieu, Hammons Gabrielle M, Melnick Nikkol, Carlone George M, Sampson Jacquelyn S, Ades Edwin W

出版信息

Clin Vaccine Immunol. 2010 Nov;17(11):1823-4. doi: 10.1128/CVI.00366-10. Epub 2010 Sep 15.

DOI:10.1128/CVI.00366-10
PMID:20844085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2976101/
Abstract
摘要