University of São Paulo, São Paulo, Brazil.
PLoS One. 2010 Sep 9;5(9):e12652. doi: 10.1371/journal.pone.0012652.
Common variable immunodeficiency disorder (CVID) is the commonest cause of primary antibody failure in adults and children, and characterized clinically by recurrent bacterial infections and autoimmune manifestations. Several innate immune defects have been described in CVID, but no study has yet investigated the frequency, phenotype or function of the key regulatory cell population, natural killer T (NKT) cells. We measured the frequencies and subsets of NKT cells in patients with CVID and compared these to healthy controls. Our results show a skewing of NKT cell subsets, with CD4+ NKT cells at higher frequencies, and CD8+ NKT cells at lower frequencies. However, these cells were highly activated and expression CD161. The NKT cells had a higher expression of CCR5 and concomitantly expression of CCR5+CD69+CXCR6 suggesting a compensation of the remaining population of NKT cells for rapid effector action.
普通变异性免疫缺陷病（CVID）是成人和儿童原发性抗体缺陷最常见的原因，其临床特征为反复细菌感染和自身免疫表现。CVID 存在几种固有免疫缺陷，但尚无研究调查关键调节细胞群自然杀伤 T（NKT）细胞的频率、表型或功能。我们测量了 CVID 患者和健康对照者 NKT 细胞的频率和亚群。我们的结果显示 NKT 细胞亚群发生偏倚，CD4+NKT 细胞频率较高，CD8+NKT 细胞频率较低。然而，这些细胞高度激活，表达 CD161。NKT 细胞表达更高水平的 CCR5，同时表达 CCR5+CD69+CXCR6，提示 NKT 细胞的其余部分为快速效应功能而代偿。
