关于茂烯内酯核心的综合研究。
Synthetic studies on the mycolactone core.
机构信息
Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
出版信息
Org Biomol Chem. 2010 Nov 21;8(22):5159-65. doi: 10.1039/c0ob00540a. Epub 2010 Aug 19.
PMID:20844795
Abstract
Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the mycolactones.
摘要
本文提出了两种合成茂内酯聚酮大环内酯核心的方法。第一种方法将闭环复分解（RCM）嵌入两步 Julia 烯烃化反应中，而第二种方法则截取了 Kishi 的优化路线，从而为茂内酯的合成提供了正式途径。
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