Compiègne University of Technology, UMR CNRS 6022, 60206 Compiègne, France.
Anal Bioanal Chem. 2010 Nov;398(6):2481-92. doi: 10.1007/s00216-010-4158-x. Epub 2010 Sep 16.
Molecularly imprinted polymers (MIPs) are tailor-made synthetic materials possessing specific cavities designed for a target molecule. Since they recognise their target analyte with affinities and selectivities comparable to those of antibody-antigen, enzyme-substrate and ligand-receptor interactions, they are often referred to as synthetic receptors or plastic antibodies. In this review, we describe the great potential and recent developments of MIPs in affinity separations, with emphasis on their application to the solid-phase extraction (SPE) of analytes from complex matrices. Research efforts made in this field to obtain water-compatible polymers for their applicability in aqueous environments are described. We particularly discuss problems encountered in the use of MIPs in SPE and the attempts carried out to improve their efficiency.
分子印迹聚合物（MIPs）是一种定制的合成材料，具有专门设计用于目标分子的特定空腔。由于它们对目标分析物的识别具有类似于抗体-抗原、酶-底物和配体-受体相互作用的亲和力和选择性，因此它们通常被称为合成受体或塑料抗体。在本文中，我们描述了 MIPs 在亲和分离中的巨大潜力和最新进展，重点介绍了它们在复杂基质中分析物的固相萃取（SPE）中的应用。描述了在该领域为获得适用于水相环境的水兼容聚合物而进行的研究工作。我们特别讨论了在 SPE 中使用 MIPs 时遇到的问题以及为提高其效率而进行的尝试。
