枸橼酸氯米芬和左旋肉碱治疗特发性男性不育症的安全性和有效性：一项对比研究。
Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study.
作者信息
Moradi Mahmoudreza, Moradi Asaad, Alemi Mohsen, Ahmadnia Hassan, Abdi Hossein, Ahmadi Alireza, Bazargan-Hejazi Shahrzad
机构信息
Fertility-Infertility Research Center, Urology and Nephrology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Urol J. 2010 Summer;7(3):188-93.
PURPOSE
To compare the effects of L-carnitine with clomiphene citrate in idiopathic infertile men.
MATERIALS AND METHODS
Fifty-two men with idiopathic infertility were recruited in this randomized controlled trial. They were randomly assigned into 2 treatment groups, group 1 (n = 20) and group 2 (n = 32), who received L-carnitine 25 mg/day and clomiphene citrate 2 gr/day, respectively, for a period of 3 months.
RESULTS
Comparing the effect of L-carnitine and clomiphene on sperm parameters before and after the treatment, both medications had influence on sperm count and motility (P = .01). L-carnitine significantly increased the semen volume (P = .001), while clomiphene citrate was significantly associated with the motility percentage and normal morphology (P = .008).
CONCLUSION
It seems that the use of clomiphene citrate and L-carnitine, either individually or in combination, as the first step of idiopathic male infertility treatment is reasonable, safe, and effective.
目的
比较左旋肉碱与枸橼酸氯米芬对特发性不育男性的治疗效果。
材料与方法
在这项随机对照试验中招募了52名特发性不育男性。他们被随机分为2个治疗组，第1组（n = 20）和第2组（n = 32），分别接受25毫克/天的左旋肉碱和2克/天的枸橼酸氯米芬治疗，为期3个月。
结果
比较左旋肉碱和枸橼酸氯米芬治疗前后对精子参数的影响，两种药物均对精子数量和活力有影响（P = .01）。左旋肉碱显著增加精液量（P = .001），而枸橼酸氯米芬与活力百分比和正常形态显著相关（P = .008）。
结论
看来，单独或联合使用枸橼酸氯米芬和左旋肉碱作为特发性男性不育治疗的第一步是合理、安全且有效的。
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