Torres-Arce Elizabeth, Vizmanos Barbara, Babio Nancy, Márquez-Sandoval Fabiola, Salas-Huetos Albert
Center of Health Sciences, Institute of Translational Nutrigenetics and Nutrigenomics, Universidad de Guadalajara, 44340 Guadalajara, Mexico.
Andrology and IVF Laboratory, Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.
Biology (Basel). 2021 Mar 20;10(3):241. doi: 10.3390/biology10030241.
Infertility affects about 15% of the population and male factors only are responsible for ~25-30% of cases of infertility. Currently, the etiology of suboptimal semen quality is poorly understood, and many environmental and genetic factors, including oxidative stress, have been implicated. Oxidative stress is an imbalance between the production of free radicals, or reactive oxygen species (ROS), and the capacity of the body to counteract their harmful effects through neutralization by antioxidants. The purpose of this review, by employing the joint expertise of international researchers specialized in nutrition and male fertility areas, is to update the knowledge about the reproductive consequences of excessive ROS concentrations and oxidative stress on the semen quality and Assisted Reproduction Techniques (ART) clinical outcomes, to discuss the role of antioxidants in fertility outcomes, and finally to discuss why foods and dietary patterns are more innocuous long term solution for ameliorating oxidative stress and therefore semen quality results and ART fertility outcomes. Since this is a narrative review and not a systematic/meta-analysis, the summarized information in the present study should be considered cautiously.
不孕症影响着约15%的人口，仅男性因素就导致了约25%-30%的不孕病例。目前，对精液质量欠佳的病因了解甚少，许多环境和遗传因素，包括氧化应激，都被认为与之有关。氧化应激是自由基或活性氧（ROS）的产生与身体通过抗氧化剂中和来抵消其有害影响的能力之间的失衡。本综述借助营养和男性生育领域国际研究人员的联合专业知识，旨在更新关于过量ROS浓度和氧化应激对精液质量及辅助生殖技术（ART）临床结局的生殖影响的知识，讨论抗氧化剂在生育结局中的作用，最后探讨为何食物和饮食模式是改善氧化应激从而改善精液质量结果及ART生育结局的更无害的长期解决方案。由于这是一篇叙述性综述而非系统评价/荟萃分析，本研究中总结的信息应谨慎看待。
