改良人工胃模型评价中药方剂的抗酸作用。
Antacid effects of Chinese herbal prescriptions assessed by a modified artificial stomach model.
机构信息
Chinese Medicine Pharmacy Department, E-Da Hospital, Kaohsiung 824, Taiwan, China.
出版信息
World J Gastroenterol. 2010 Sep 21;16(35):4455-9. doi: 10.3748/wjg.v16.i35.4455.
AIM
To assess the antacid effects of the tonic Chinese herbal prescriptions, si-jun-zi-tang (SJZT) and shen-ling-bai-zhu-san (SLBZS).
METHODS
Decoctions of the tonic Chinese herbal prescriptions, SJZT and SLBZS, were prepared according to Chinese original documents. The pH of the prescription decoctions and their neutralizing effects on artificial gastric acids were determined and compared with water and the active controls, sodium bicarbonate and colloidal aluminum phosphate. A modified model of Vatier's artificial stomach was used to determine the duration of consistent neutralization effect on artificial gastric acids. The neutralization capacity in vitro was determined with the titration method of Fordtran's model.
RESULTS
The results showed that both SJZT and SLBZS have antacid effects in vitro. Compared with the water group, SJZT and SLBZS were found to possess significant gastric acid neutralizing effects. The duration for consistent neutralization of SLBZS was significantly longer than that of water. Also, SLBZS and SJZT exhibited significant antacid capacities compared to water.
CONCLUSION
SJZT and SLBZS were consistently active in the artificial stomach model and are suggested to have antacid effects similar to the active control drugs.
目的
评估滋补中药方剂四君子汤（SJZT）和参苓白术散（SLBZS）的抗酸作用。
方法
根据中文原文制备滋补中药方剂 SJZT 和 SLBZS 的汤剂。测定方剂汤剂的 pH 值及其对人工胃酸的中和作用，并与水和活性对照物碳酸氢钠和胶体磷酸铝进行比较。使用 Vatier 的人工胃改良模型来确定对人工胃酸持续中和作用的时间。采用 Fordtran 模型的滴定法测定体外中和能力。
结果
结果表明，SJZT 和 SLBZS 均具有体外抗酸作用。与水组相比，SJZT 和 SLBZS 均具有显著的胃酸中和作用。SLBZS 的持续中和时间明显长于水组。此外，SLBZS 和 SJZT 的抗酸能力明显优于水组。
结论
SJZT 和 SLBZS 在人工胃模型中持续有效，提示其具有与活性对照药物相似的抗酸作用。
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