发热性胆汁淤积性疾病作为结节性淋巴细胞为主型霍奇金淋巴瘤的初始表现。
Febrile cholestatic disease as an initial presentation of nodular lymphocyte-predominant Hodgkin lymphoma.
机构信息
University of Zagreb, School of Medicine, Salata 3, 10000 Zagreb, Croatia.
出版信息
World J Gastroenterol. 2010 Sep 21;16(35):4491-3. doi: 10.3748/wjg.v16.i35.4491.
Abstract
Febrile cholestatic liver disease is an extremely unusual presentation of Hodgkin lymphoma (HL). The liver biopsy of a 40-year-old man with febrile episodes and cholestatic laboratory pattern disclosed an uncommon subtype of HL, a nodular lymphocyte-predominant HL (NLPHL). Liver involvement in the early stage of the usually indolent NLPHL's clinical course suggests an aggressiveness and unfavorable outcome. Emphasizing a liver biopsy early in the diagnostic algorithm enables accurate diagnosis and appropriate treatment. Although rare, HL should be considered in the differential diagnosis of cholestasis.
摘要
发热性胆汁淤积性肝病是霍奇金淋巴瘤（HL）极不常见的表现。一位 40 岁男性因发热和胆汁淤积性实验室表现进行了肝活检，结果显示为一种不常见的 HL 亚型，即结节性淋巴细胞为主型 HL（NLPHL）。在通常惰性的 NLPHL 临床病程的早期，肝脏受累提示侵袭性和不良预后。在诊断算法中早期强调肝活检可实现准确诊断和适当治疗。尽管罕见，但在胆汁淤积的鉴别诊断中应考虑 HL。
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