[细柱五加茎的化学成分研究]

[Studies on the chemical constituents from the stems of Acanthopanax gracilistylus].

作者信息

Xian Li-N, Qian Shi-Hui, Li Zhen-Lin

机构信息

Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China.

出版信息

Zhong Yao Cai. 2010 Apr;33(4):538-42.

PMID:20845778

Abstract

OBJECTIVE

To study the chemical constituents from the stems of Acanthopanax gracilistylus.

METHODS

The chemical constituents of the plant were isolated and puried by column chromatography and their structures were elucidated on the basis of physico-chemical properties and spectral data.

RESULTS

Sixteen compounds were isolated and identified as (2S,3S, 4R, 8E)-2-[(2'R)-2'-hydroxy-pentadecanoylamino]-heptacosane-1,3,4-triol-8-ene(1a),(2S,3S,4R,8E)-2-[(2'R)-2'-hydroxy-octadecanoylamino]-lignocer-ane-1,3,4-triol-8-ene(1b), (2S, 3S, 4R, 8E) -2-[(2'R) -2'-hydroxy-heneicosanoylamino]-heneicosane-1,3,4-triol-8-ene (1c), (2S, 3S,4R, 8E)-2-[(2'R) -2'-hydroxy-docosanoylamino] -eicosane-1,3,4-triol-8-ene (1d), (2S, 3S, 4R, 8E)-2-[(2'R)-2'-hydroxy-trico-sanoylamino]-nonadecane-1,3,4-triol-8-ene (1e), (2S,3S,4R,8E)-2-[(2'R)-2'-hydroxy-lignocera-noylamino]-cctadecane-1,3,4-tri-ol-8-ene(1f), 1-O-beta-D-glucopyranosyl-(2S, 3S, 4R, 8E)-2-[(2'R)-2'-hydroxy-pentadecanoylamino]-nonadecane-1, 3, 4-triol-8-ene (2), 16alpha-hydroxy-ent-kauran-19-ocid (3), 16alphaH, 17-isovaleryloxy-ent-kauran-19-oic acid (4), coniferin (5), syringin (6), eleutheroside D (7), stigmasterol (8), beta-sitosterol (9), daucosterol (10), pentacosanoic acid (11).

CONCLUSION

Compounds 1a - f, 2 are isolated from this genus for the first time, and compounds 4, 5, 11 are firstly obtained from Acanthopanax gracilistylus.

摘要

目的

研究细柱五加茎的化学成分。

方法

采用柱色谱法对该植物的化学成分进行分离纯化，并根据理化性质和光谱数据对其结构进行鉴定。

结果

分离得到16个化合物，分别鉴定为(2S,3S,4R,8E)-2-[(2'R)-2'-羟基-十五烷酰氨基]-二十七烷-1,3,4-三醇-8-烯(1a)、(2S,3S,4R,8E)-2-[(2'R)-2'-羟基-十八烷酰氨基]-木蜡烷-1,3,4-三醇-8-烯(1b)、(2S,3S,4R,8E)-2-[(2'R)-2'-羟基-二十一烷酰氨基]-二十一烷-1,3,4-三醇-8-烯(1c)、(2S,3S,4R,8E)-2-[(2'R)-2'-羟基-二十二烷酰氨基]-二十烷-1,3,4-三醇-8-烯(1d)、(2S,3S,4R,8E)-2-[(2'R)-2'-羟基-二十三烷酰氨基]-十九烷-1,3,4-三醇-8-烯(1e)、(2S,3S,4R,8E)-2-[(2'R)-2'-羟基-木蜡酰氨基]-十八烷-1,3,4-三醇-8-烯(1f)、1-O-β-D-吡喃葡萄糖基-(2S,3S,4R,8E)-2-[(2'R)-2'-羟基-十五烷酰氨基]-十九烷-1,3,4-三醇-8-烯(2)、16α-羟基-对映-贝壳杉烷-19-酸(3)、16αH,17-异戊酰氧基-对映-贝壳杉烷-19-酸(4)、松柏苷(5)、紫丁香苷(6)、刺五加苷D(7)、豆甾醇(8)、β-谷甾醇(9)、胡萝卜苷(10)、二十五烷酸(11)。